Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1-Reference-Cited by-同舟云学术

Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1

Published:2020-05-06 Issue:542 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Eberhard Johanna M.¹²^ORCID,Angin Mathieu³^ORCID,Passaes Caroline³^ORCID,Salgado Maria⁴^ORCID,Monceaux Valerie³,Knops Elena⁵^ORCID,Kobbe Guido⁶^ORCID,Jensen Björn⁷^ORCID,Christopeit Maximilian⁸^ORCID,Kröger Nicolaus⁸,Vandekerckhove Linos⁹,Badiola Jon¹⁰^ORCID,Bandera Alessandra¹¹^ORCID,Raj Kavita¹²,van Lunzen Jan¹¹³,Hütter Gero¹⁴,Kuball Jürgen H. E.¹⁵^ORCID,Martinez-Laperche Carolina¹⁶^ORCID,Balsalobre Pascual¹⁶,Kwon Mi¹⁶^ORCID,Díez-Martín José L.¹⁶,Nijhuis Monique¹⁵^ORCID,Wensing Annemarie¹⁵^ORCID,Martinez-Picado Javier⁴¹⁷¹⁸^ORCID,Schulze zur Wiesch Julian¹²^ORCID,Sáez-Cirión Asier³^ORCID

Affiliation:

1. 1. Department of Medicine, Infectious Diseases Unit, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany.

2. DZIF Partner Site (German Center for Infection Research), Hamburg-Lübeck-Borstel-Riems Site, Hamburg, Germany.

3. Institut Pasteur, HIV, Inflammation and Persistence, 75015 Paris, France.

4. AIDS Research Institute IrsiCaixa, 08916 Badalona, Spain.

5. Institute of Virology, University of Cologne, 50935 Cologne, Germany.

6. Department of Haematology, Oncology, and Clinical Immunology, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.

7. Department of Gastroenterology, Hepatology, and Infectious Diseases, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.

8. Department of Stem Cell Transplantation, University Medical Center HamburgEppendorf, 20246 Hamburg, Germany.

9. HIV Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital, B-9000 Ghent, Belgium.

10. Hematology Department, Virgen de las Nieves University Hospital, 18014 Granada, Spain.

11. San Gerardo Hospital, University of Milano-Bicocca, 20900 Monza, Italy.

12. Department of Haematology, King's College Hospital, London SE5 9RS, UK.

13. ViiV Healthcare, Brentford, Middlesex TW8 9GS, UK.

14. Cellex, 01307 Dresden, Germany.

15. University Medical Center Utrecht, 3584 CX, Utrecht, Netherlands.

16. Hospital Universitario Gregorio Marañón, Instituto de Investigación Sanitarias Gregorio Marañón, Universidad Complutense, 28007 Madrid, Spain.

17. UVic-UCC, 08500 Vic, Spain.

18. ICREA, 08010 Barcelona, Spain.

Abstract

Heterogenous immune reconstitution and de novo priming of HIV-specific T cells characterize allo-HSCT recovery in HIV-infected individuals.

Funder