Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide-Reference-Cited by-同舟云学术

Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide

Published:2020-10-07 Issue:564 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Montiel Virginie¹^ORCID,Bella Ramona¹,Michel Lauriane Y. M.¹^ORCID,Esfahani Hrag¹,De Mulder Delphine¹,Robinson Emma L.²,Deglasse Jean-Philippe³^ORCID,Tiburcy Malte⁴⁵^ORCID,Chow Pak Hin⁶,Jonas Jean-Christophe³^ORCID,Gilon Patrick³^ORCID,Steinhorn Benjamin⁷,Michel Thomas⁷^ORCID,Beauloye Christophe⁸,Bertrand Luc⁸^ORCID,Farah Charlotte¹,Dei Zotti Flavia¹,Debaix Huguette⁹¹⁰,Bouzin Caroline¹¹^ORCID,Brusa Davide¹²^ORCID,Horman Sandrine⁸^ORCID,Vanoverschelde Jean-Louis⁸^ORCID,Bergmann Olaf¹³¹⁴^ORCID,Gilis Dimitri¹⁵,Rooman Marianne¹⁵,Ghigo Alessandra¹⁶^ORCID,Geninatti-Crich Simonetta¹⁷^ORCID,Yool Andrea⁶^ORCID,Zimmermann Wolfram H.⁴⁵¹⁸^ORCID,Roderick H. Llewelyn²^ORCID,Devuyst Olivier⁹¹⁰,Balligand Jean-Luc¹^ORCID

Affiliation:

1. Institute of Experimental and Clinical Research (IREC), Pharmacology and Therapeutics (FATH), Cliniques Universitaires St Luc and Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium.

2. Laboratory of Experimental Cardiology, Department of Cardiovascular Sciences, KULeuven, 3000 Leuven, Belgium.

3. Institute of Experimental and Clinical Research (IREC), Endocrinology, Diabetes and Nutrition (EDIN), Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium.

4. Institute of Pharmacology and Toxicology, University Medical Center Göttingen, 37075 Göttingen, Germany.

5. DZHK (German Center for Cardiovascular Research), Partner Site Göttingen, 37075 Göttingen, Germany.

6. Adelaide Medical School, University of Adelaide, Adelaide, SA 5000, Australia.

7. Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 2115, USA.

8. Institute of Experimental and Clinical Research (IREC), Pole of Cardiovascular Research (CARD), Cliniques Universitaires St Luc and Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium.

9. Institute of Experimental and Clinical Research (IREC), Nephrology (NEFR), Cliniques Universitaires St Luc and Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium.

10. Institute of Physiology, University of Zürich, CH 8057 Zürich, Switzerland.

11. 2IP-IREC Imaging Platform, Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium.

12. Flow Cytometry Platform, Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain (UCLouvain), 1200 Brussels, Belgium.

13. Center for Regenerative Therapies Dresden, Technische Universität Dresden, 01062 Dresden, Germany.

14. Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden.

15. Computational Biology and Bioinformatics (3BIO-BioInfo), Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium.

16. Molecular Biotechnology Center, Università di Torino, 10124 Torino, Italy.

17. Molecular Biotechnology and Health Sciences, Università di Torino, 10124 Torino, Italy.

18. Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen, 37075 Göttingen, Germany.

Abstract

Pharmacological inhibition of AQP1 prevents H 2 O 2 transport and hypertrophy of cardiac myocytes.

Funder

Deutsche Forschungsgemeinschaft

Swiss National Science Foundation

Fonds De La Recherche Scientifique - FNRS

Fédération Wallonie-Bruxelles

Fonds Wetenschappelijk Onderzoek

WELBIO

Publisher

American Association for the Advancement of Science (AAAS)

Subject