TORC1 inhibition enhances immune function and reduces infections in the elderly-Reference-Cited by-同舟云学术

TORC1 inhibition enhances immune function and reduces infections in the elderly

Published:2018-07-11 Issue:449 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Mannick Joan B.¹^ORCID,Morris Melody¹,Hockey Hans-Ulrich P.²^ORCID,Roma Guglielmo³^ORCID,Beibel Martin³,Kulmatycki Kenneth¹,Watkins Mollie¹,Shavlakadze Tea¹,Zhou Weihua¹,Quinn Dean⁴,Glass David J.¹^ORCID,Klickstein Lloyd B.¹^ORCID

Affiliation:

1. Novartis Institutes for Biomedical Research, Cambridge, MA 02139, USA.

2. Biometrics Matters Limited, Hamilton 3216, New Zealand.

3. Novartis Institutes for Biomedical Research, Novartis Campus, 4056 Basel, Switzerland.

4. P3 Research, Newtown, Wellington 6242, New Zealand.

Abstract

Treating elderly subjects with two low-dose mTOR inhibitors that selectively block TORC1 led to a decrease in infection rates.

Funder

Novartis

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference26 articles.

1. The Hallmarks of Aging

2. mTOR is a key modulator of ageing and age-related disease

3. mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

4. S. L. Murphy X. Jiaquan K. D. Kochnanek Deaths: Final Data for 2010 (National Vital Statistics Report 2013).

5. National Center for Health Statistics Health United States 2015: With Special Feature on Racial and Ethnic Health Disparities (2016).

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