The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs-Reference-Cited by-同舟云学术

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

Published:2019-06-12 Issue:496 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Virtue Anthony T.¹²^ORCID,McCright Sam J.¹²^ORCID,Wright Jasmine M.¹²^ORCID,Jimenez Monica T.¹²^ORCID,Mowel Walter K.¹²^ORCID,Kotzin Jonathan J.¹²^ORCID,Joannas Leonel¹²^ORCID,Basavappa Megha G.¹²³,Spencer Sean P.¹²^ORCID,Clark Megan L.¹²^ORCID,Eisennagel Stephen H.⁴,Williams Adam⁵^ORCID,Levy Maayan²³⁶,Manne Sasikanth⁷,Henrickson Sarah E.²⁸,Wherry E. John²⁷⁹^ORCID,Thaiss Christoph A.²³⁶,Elinav Eran⁶^ORCID,Henao-Mejia Jorge¹²¹⁰^ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Core DMPK, GlaxoSmithKline, Collegeville, PA 19426, USA.

5. Jackson Laboratory for Genomic Medicine, Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT 06032, USA.

6. Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.

7. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, Philadelphia, PA 19104, USA.

8. Division of Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

9. Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

10. Division of Protective Immunity, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Tryptophan-derived metabolites from the gut microbiota control miR-181 expression in mouse white adipocytes to regulate metabolism and inflammation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

1. Developmental Origin of Fat: Tracking Obesity to Its Source

2. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

3. Microbiota depletion promotes browning of white adipose tissue and reduces obesity

4. The gut microbiota as an environmental factor that regulates fat storage

5. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

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