Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease-Reference-Cited by-同舟云学术

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

Published:2019-08-28 Issue:507 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ewers Michael¹^ORCID,Franzmeier Nicolai¹^ORCID,Suárez-Calvet Marc²³⁴⁵^ORCID,Morenas-Rodriguez Estrella²⁶,Caballero Miguel Angel Araque¹,Kleinberger Gernot²⁷⁸,Piccio Laura⁹¹⁰¹¹,Cruchaga Carlos¹⁰¹²^ORCID,Deming Yuetiva¹⁰¹²^ORCID,Dichgans Martin¹³⁷^ORCID,Trojanowski John Q.¹³^ORCID,Shaw Leslie M.¹⁴,Weiner Michael W.¹⁵,Haass Christian²³⁷^ORCID,

Affiliation:

1. Institute for Stroke and Dementia Research, University Hospital Munich, LMU, Munich, Germany.

2. Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

3. German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.

4. Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation. Barcelona, Catalonia, Spain.

5. Department of Neurology, Hospital del Mar, Barcelona, Catalonia, Spain.

6. Department of Neurology, Institut d’Investigacions Biomèdiques, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

7. Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

8. ISAR Bioscience GmbH, 82152 Planegg, Germany.

9. Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.

10. Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.

11. Brain and Mind Centre, University of Sydney, Sydney, Australia.

12. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.

13. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

14. Center for Neurodegenerative Disease Research, Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

15. University of California at San Francisco, San Francisco, CA, USA.

Abstract

Higher CSF sTREM2 concentrations are associated with slower rates of cognitive decline in subjects with Alzheimer’s disease.

Funder

National Institutes of Health

U.S. Department of Defense

Deutsche Forschungsgemeinschaft

Cure Alzheimer’s Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine