A microRNA-21–mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis

Author:

Kim Richard Y.12ORCID,Sunkara Krishna P.234ORCID,Bracke Ken R.5ORCID,Jarnicki Andrew G.6,Donovan Chantal12ORCID,Hsu Alan C.2ORCID,Ieni Antonio7,Beckett Emma L.2ORCID,Galvão Izabela1ORCID,Wijnant Sara5,Ricciardolo Fabio LM.8ORCID,Di Stefano Antonino9ORCID,Haw Tatt Jhong2ORCID,Liu Gang1ORCID,Ferguson Angela L.1011ORCID,Palendira Umamainthan10ORCID,Wark Peter A.2ORCID,Conickx Griet512ORCID,Mestdagh Pieter13ORCID,Brusselle Guy G.5ORCID,Caramori Gaetano14ORCID,Foster Paul S.2ORCID,Horvat Jay C.2,Hansbro Philip M.12ORCID

Affiliation:

1. Centre for Inflammation, Centenary Institute and University of Technology Sydney, Sydney, New South Wales 2007, Australia.

2. Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and University of Newcastle, Newcastle, New South Wales 2308, Australia.

3. Graduate School of Health, Discipline of Pharmacy, University of Technology Sydney, Sydney, New South Wales 2007, Australia.

4. Intensive Care Unit, John Hunter Hospital, Newcastle, New South Wales 2308, Australia.

5. Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent 9000, Belgium.

6. Department of Biochemistry and Pharmacology, University of Melbourne, Victoria 3010, Australia.

7. Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, Section of Anatomic Pathology, University of Messina, Messina 98100, Italy.

8. Rare Lung Disease Unit, Department of Clinical and Biological Sciences, University of Torino, San Luigi Gonzaga University Hospital Orbassano, Torino 10043, Italy.

9. Istituti Clinici Scientifici Maugeri, IRCCS, SpA Società Benefit, Divisione di Pneumologia e Laboratorio di Citoimmunopatologia dell’Apparato Cardio Respiratorio, Veruno, Novara 28100, Italy.

10. Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia.

11. Centenary Institute and University of Technology Sydney, Sydney, New South Wales 2006, Australia.

12. Ablynx N.V., a Sanofi company, Ghent 9052, Belgium.

13. Center for Medical Genetics and Cancer Research Institute Ghent (CRIG), Ghent University, Ghent 9000, Belgium.

14. Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina 98100, Italy.

Abstract

Inhibition of cigarette smoke–induced microRNA-21 suppresses chronic obstructive pulmonary disease through effects on a SATB1/S100A9/NF-κB axis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference89 articles.

1. WHO Chronic obstructive pulmonary disease (COPD) (Fact Sheet 315 WHO 2017).

2. Animal models of chronic obstructive pulmonary disease

3. Animal models of COPD: What do they tell us?

4. Pulmonary-intestinal cross-talk in mucosal inflammatory disease

5. Asthma, COPD and when they coexist;Wark P. A.;Med. Today,2016

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