Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development-Reference-Cited by-全球学者库

Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

Published:2019-04-03 Issue:486 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kang Donghyun¹²^ORCID,Shin Jungkwon¹²^ORCID,Cho Yongsik¹²,Kim Hyeon-Seop¹²,Gu Young-Ran¹²,Kim Haedong¹²^ORCID,You Kwon Tae¹²,Chang Moon Jong³,Chang Chong Bum³^ORCID,Kang Seung-Baik³,Kim Jong-Seo¹²^ORCID,Kim V. Narry¹²^ORCID,Kim Jin-Hong¹²⁴^ORCID

Affiliation:

1. Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.

2. Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.

3. Department of Orthopedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061 Seoul, South Korea.

4. Interdisciplinary Program in Bioinformatics, Seoul National University, 08826 Seoul, South Korea.

Abstract

Senescence-induced miR-204 alters the proteoglycan biosynthesis pathway and disrupts matrix homeostasis in osteoarthritic cartilage.

Funder

Ministry of Health and Welfare

Seoul National University

Ministry of Science, ICT and Future Planning

National Research Foundation of Korea

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference97 articles.

1. Extracellular matrix assembly: a multiscale deconstruction

2. Aggrecan, aging and assembly in articular cartilage

3. Synthesis and sorting of proteoglycans

4. Structure and function of aggrecan

5. Osteoarthritis: A disease of the joint as an organ

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