Modeling the impact on virus transmission of Wolbachia -mediated blocking of dengue virus infection of Aedes aegypti-Reference-Cited by-同舟云学术

Modeling the impact on virus transmission of Wolbachia -mediated blocking of dengue virus infection of Aedes aegypti

Published:2015-03-18 Issue:279 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ferguson Neil M.¹,Hue Kien Duong Thi²,Clapham Hannah¹,Aguas Ricardo¹,Trung Vu Tuan²,Bich Chau Tran Nguyen²,Popovici Jean³,Ryan Peter A.³,O’Neill Scott L.³,McGraw Elizabeth A.³,Long Vo Thi²,Dui Le Thi²,Nguyen Hoa L.²,Vinh Chau Nguyen Van⁴,Wills Bridget²⁵,Simmons Cameron P.²⁵⁶

Affiliation:

1. Medical Research Council Centre for Outbreak Analysis and Modelling, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.

2. Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 764 Võ Vǎn Kiêt, District 5, Ho Chi Minh City 748010, Vietnam.

3. School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia.

4. Hospital for Tropical Diseases, 190 Ben Hám Tú, District 5, Ho Chi Minh City 748010, Vietnam.

5. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX1 7FZ, UK.

6. Department of Microbiology and Immunology and Nossal Institute of Global Health, University of Melbourne, Carlton, Victoria 3010, Australia.

Abstract

Experimental work and modeling studies reveal that Aedes aegypti infected with the Wolbachia bacterium have reduced vector competence for the transmission of dengue viruses.

Funder

NIH

Bill and Melinda Gates Foundation (BMGF)

Wellcome Trust

European Union Seventh Framework Programme European

Medical Research Council

National Health and Medical Research Council

National Institute of General Medical Sciences Models of Infectious Disease Agent Study initiative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine