A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice-Reference-Cited by-同舟云学术

A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice

Published:2015-03-18 Issue:279 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tian Ying¹²,Liu Ying¹,Wang Tao¹,Zhou Ning¹³,Kong Jun¹,Chen Li¹,Snitow Melinda¹,Morley Michael¹,Li Deqiang¹,Petrenko Nataliya¹²,Zhou Su¹,Lu Minmin¹,Gao Erhe²,Koch Walter J.²,Stewart Kathleen M.¹,Morrisey Edward E.¹⁴⁵⁶

Affiliation:

1. Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Pharmacology, Center for Translational Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.

3. Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China.

4. Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA19104, USA.

5. Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

6. Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

A microRNA-based therapeutic approach could be used to promote cardiac regeneration through the transient activation of cardiomyocyte proliferation.

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference42 articles.

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4. Mammalian heart renewal by pre-existing cardiomyocytes

5. Small changes can make a big difference — MicroRNA regulation of cardiac hypertrophy

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