A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters-Reference-Cited by-同舟云学术

A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters

Published:2021-08-11 Issue:606 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wu Yangtao¹^ORCID,Huang Xiaofen¹,Yuan Lunzhi¹^ORCID,Wang Shaojuan¹,Zhang Yali¹^ORCID,Xiong Hualong¹,Chen Rirong²³^ORCID,Ma Jian¹^ORCID,Qi Ruoyao¹^ORCID,Nie Meifeng¹,Xu Jingjing¹^ORCID,Zhang Zhigang¹^ORCID,Chen Liqiang²³^ORCID,Wei Min¹^ORCID,Zhou Ming¹,Cai Minping²³^ORCID,Shi Yang¹^ORCID,Zhang Liang¹,Yu Huan²³,Hong Junping¹,Wang Zikang¹,Hong Yunda¹^ORCID,Yue Mingxi¹,Li Zonglin¹,Chen Dabing¹^ORCID,Zheng Qingbing¹^ORCID,Li Shaowei¹^ORCID,Chen Yixin¹^ORCID,Cheng Tong¹^ORCID,Zhang Jun¹^ORCID,Zhang Tianying¹^ORCID,Zhu Huachen²³^ORCID,Zhao Qinjian¹^ORCID,Yuan Quan¹^ORCID,Guan Yi²³^ORCID,Xia Ningshao¹⁴^ORCID

Affiliation:

1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences & School of Public Health, Xiamen University, Xiamen 361102, P. R. China.

2. State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong 999077, P. R. China.

3. Joint Institute of Virology (Shantou University and University of Hong Kong), Guangdong-Hongkong Joint Laboratory of Emerging Infectious Diseases, Shantou University, Shantou 515063, P. R. China.

4. Research Unit of Frontier Technology of Structural Vaccinology, Chinese Academy of Medical Sciences, Xiamen 361102, Fujian, China.

Abstract

A SARS-CoV-2 spike protein subunit vaccine induced humoral and cellular immune responses that protected hamsters against infection and prevented transmission.

Funder

National Natural Science Foundation of China

National Key Plan for Scientific Research and Development of China

Funding for Guangdong-Hongkong-Macau Joint Laboratory

Fujian Natural Science Foundation for Distinguished Young Scholars

The Bill &Melinda Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference60 articles.

1. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor