Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates

Author:

Badi Marion1ORCID,Wurth Sophie1ORCID,Scarpato Ilaria1ORCID,Roussinova Evgenia1,Losanno Elena2ORCID,Bogaard Andrew3ORCID,Delacombaz Maude3,Borgognon Simon34ORCID,C̆vanc̆ara Paul5ORCID,Fallegger Florian6ORCID,Su David K.7,Schmidlin Eric3ORCID,Courtine Grégoire48ORCID,Bloch Jocelyne8ORCID,Lacour Stéphanie P.6ORCID,Stieglitz Thomas5ORCID,Rouiller Eric M.3ORCID,Capogrosso Marco39ORCID,Micera Silvestro12ORCID

Affiliation:

1. Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics, and Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

2. Biorobotics Institute and Department of Excellence in Robotics and AI, Scuola Superiore Sant’Anna, 56025 Pisa, Italy.

3. Department of Neuroscience and Movement Sciences, Platform of Translational Neurosciences, Section of Medicine, Faculty of Sciences and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.

4. Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, EPFL, 1015 Lausanne, Switzerland.

5. Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering–IMTEK, Bernstein Center Freiburg, and BrainLinks-BrainTools Center, University of Freiburg, 79110 Freiburg, Germany.

6. Bertarelli Foundation Chair in Neuroprosthetic Technology, Laboratory for Soft Bioelectronics Interface, Institute of Microengineering, Institute of Bioengineering, Centre for Neuroprosthetics, 1202 Geneva, Switzerland.

7. Neurological Surgery, Harborview Medical Center, Seattle, WA 98104, USA.

8. Defitech Center for Interventional Neurotherapies (NeuroRestore), EPFL, University Hospital of Lausanne (CHUV), and University of Lausanne (UNIL), 1015 Lausanne, Switzerland.

9. Department of Neurological Surgery, Rehabilitation and Neural Engineering Laboratories, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Abstract

Intrafascicular stimulation evokes precise and functional hand movements in monkeys, suggesting clinical opportunities for people with hand paralysis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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