Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors-Reference-Cited by-同舟云学术

Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors

Published:2021-10-13 Issue:615 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bellail Anita C.¹²³^ORCID,Jin Hong Ri¹^ORCID,Lo Ho-Yin⁴,Jung Sung Han¹^ORCID,Hamdouchi Chafiq¹^ORCID,Kim Daeho¹^ORCID,Higgins Ryan K.¹,Blanck Maximilian⁵^ORCID,le Sage Carlos⁵,Cross Benedict C.S.⁵^ORCID,Li Jing⁶,Mosley Amber L.²⁷^ORCID,Wijeratne Aruna B.⁷^ORCID,Jiang Wen⁸^ORCID,Ghosh Manali⁸,Zhao Yin Quan¹^ORCID,Hauck Paula M.¹^ORCID,Shekhar Anantha⁹,Hao Chunhai¹²¹⁰^ORCID

Affiliation:

1. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

2. Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA.

3. HB Therapeutics Inc., Indianapolis, IN 46202, USA.

4. Synovel Laboratory LLC, Danbury, CT 06811, USA.

5. Horizon Discovery, Cambridge, CB25 9TL, UK.

6. Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.

7. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

8. Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN 47907, USA.

9. Department of Psychiatry and Indiana Clinical and Translational Sciences Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

10. Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Abstract

Small-molecule degraders of SUMO1 induce its ubiquitination and degradation through binding of CAPRIN1 in tumor cells in vitro and in vivo.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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