Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes

Author:

Axelsson Annika S.1ORCID,Tubbs Emily1ORCID,Mecham Brig2ORCID,Chacko Shaji3ORCID,Nenonen Hannah A.1ORCID,Tang Yunzhao1,Fahey Jed W.4ORCID,Derry Jonathan M. J.5,Wollheim Claes B.16ORCID,Wierup Nils1ORCID,Haymond Morey W.3ORCID,Friend Stephen H.5ORCID,Mulder Hindrik1,Rosengren Anders H.157ORCID

Affiliation:

1. Department of Clinical Sciences, Lund University Diabetes Center, Malmö, SE-20502 Malmö, Sweden.

2. Trialomics, Seattle, WA 98115, USA.

3. U.S. Department of Agriculture/Agricultural Research Service, Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

4. Departments of Medicine, Pharmacology and Molecular Sciences, and International Health, and Cullman Chemoprotection Center, Johns Hopkins University, Baltimore, MD 21205, USA.

5. Sage Bionetworks, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

6. Department of Cell Physiology and Metabolism, University Medical Center, CH-1211 Geneva, Switzerland.

7. Institute of Neuroscience and Physiology, University of Gothenburg, SE-40530 Göteborg, Sweden.

Abstract

Sulforaphane, a natural compound identified by drug repurposing, reduces hepatic glucose production and improves glucose control in type 2 diabetes.

Funder

Ragnar Söderberg Foundation

The Swedish Foundation for Strategic Research

Lantmännen Research foundation

The NovoNordisk Foundation

ALF Region Skåne

The Hjelt Foundation

Knut and Alice Wallenberg’s foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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