Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension-Reference-Cited by-同舟云学术

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension

Published:2017-02 Issue:375 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Kossmann Sabine¹²,Lagrange Jeremy¹,Jäckel Sven¹,Jurk Kerstin¹,Ehlken Moritz¹²,Schönfelder Tanja¹,Weihert Yvonne²,Knorr Maike²,Brandt Moritz²,Xia Ning³,Li Huige³,Daiber Andreas²,Oelze Matthias²,Reinhardt Christoph¹,Lackner Karl⁴,Gruber Andras⁵⁶,Monia Brett⁷,Karbach Susanne H.²,Walter Ulrich¹,Ruggeri Zaverio M.⁸,Renné Thomas⁹¹⁰,Ruf Wolfram¹¹¹¹²,Münzel Thomas²¹²,Wenzel Philip¹²¹²

Affiliation:

1. Center for Thrombosis and Hemostasis Mainz, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

2. Center for Cardiology, Cardiology I, University Medical Center Mainz, 55131 Mainz, Germany.

3. Department of Pharmacology, University Medical Center Mainz, 55131 Mainz, Germany.

4. Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, 55131 Mainz, Germany.

5. Department of Biomedical Engineering, Oregon Health and Science University, 3303 Southwest Bond Avenue, CH13B, Portland, OR 97239, USA.

6. Aronora Inc., 4640 Southwest Macadam Avenue, Suite 200A, Portland, OR 97239, USA.

7. Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.

8. Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

9. Department of Molecular Medicine and Surgery, L1:00, Karolinska Institutet, SE-171 71 Stockholm, Sweden.

10. Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.

11. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

12. DZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, University Medical Center Mainz, 55131 Mainz, Germany.

Abstract

Blockade of an inflammatory, thrombin-activated feedback loop on platelets controls high blood pressure.

Funder

Stiftung Pathobiochemie und Molekulare Diagnostik

Federal Ministry of Education and Research

German Research Society

European Research Council

NIH

Alexander von Humboldt Foundation

German Research Foundation

Stiftung Mainzer Herz

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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