Tumor-homing cytotoxic human induced neural stem cells for cancer therapy

Author:

Bagó Juli R.1,Okolie Onyi1,Dumitru Raluca2,Ewend Matthew G.34,Parker Joel S.4,Werff Ryan Vander5,Underhill T. Michael5,Schmid Ralf S.6,Miller C. Ryan46,Hingtgen Shawn D.1347

Affiliation:

1. Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. UNC Human Pluripotent Stem Cell Core Facility, Department of Genetics, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

3. Department of Neurosurgery, UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

5. Department of Cellular and Physiological Sciences, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

6. Division of Neuropathology and Department of Pathology and Laboratory Medicine, Department of Neurology and Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

7. Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

Human skin cells directly converted to induced neural stem cells seek out cancer foci and deliver therapeutic agents that inhibit glioblastoma progression.

Funder

UNC Translational and Clinical Sciences Institute

Eshelman Institute for Innovation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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