Cleavage of the leptin receptor by matrix metalloproteinase–2 promotes leptin resistance and obesity in mice-Reference-Cited by-同舟云学术

Cleavage of the leptin receptor by matrix metalloproteinase–2 promotes leptin resistance and obesity in mice

Published:2018-08-22 Issue:455 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Mazor Rafi¹^ORCID,Friedmann-Morvinski Dinorah²³⁴^ORCID,Alsaigh Tom¹^ORCID,Kleifeld Oded⁵^ORCID,Kistler Erik B.¹⁶⁷^ORCID,Rousso-Noori Liat³⁴^ORCID,Huang Cheng⁵^ORCID,Li Joyce B.¹^ORCID,Verma Inder M.²^ORCID,Schmid-Schönbein Geert W.¹^ORCID

Affiliation:

1. Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

2. Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

3. Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

4. Sagol School of Neurosciences, Tel Aviv University, Tel Aviv 69978, Israel.

5. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.

6. Veterans Affairs San Diego Healthcare System, San Diego, CA 92093, USA.

7. Department of Anesthesiology and Critical Care, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Matrix metalloproteinase–2 inhibition rescued leptin receptor expression in the hypothalamus and reduced fat accumulation in rodent models of obesity.

Funder

NIH

NCI

AHA

Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Career Development Award

Foundation for Anesthesia Education & Research and the American Society of Critical Care Anesthesiologists

Leona M. and Harry B. Helmsley Charitable Trust and Berger foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.