Alloantigen-specific type 1 regulatory T cells suppress through CTLA-4 and PD-1 pathways and persist long-term in patients

Author:

Chen Pauline P.1ORCID,Cepika Alma-Martina1ORCID,Agarwal-Hashmi Rajni1ORCID,Saini Gopin12ORCID,Uyeda Molly J.13,Louis David M.4ORCID,Cieniewicz Brandon1ORCID,Narula Mansi1,Amaya Hernandez Laura C.3ORCID,Harre Nicholas1ORCID,Xu Liwen156,Thomas Benjamin Craig1,Ji Xuhuai6ORCID,Shiraz Parveen5ORCID,Tate Keri M.7ORCID,Margittai Dana7ORCID,Bhatia Neehar7ORCID,Meyer Everett15ORCID,Bertaina Alice12ORCID,Davis Mark M.489ORCID,Bacchetta Rosa12ORCID,Roncarolo Maria Grazia123ORCID

Affiliation:

1. Division of Hematology, Oncology, Stem Cell Transplantation, and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Center for Definitive and Curative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

3. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

4. Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.

5. Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

6. Stanford Functional Genomics Facility, Stanford University School of Medicine, Stanford, CA 94305, USA.

7. Stanford Laboratory for Cell and Gene Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

8. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

9. Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Type 1 regulatory T cells suppress alloreactive immune cells after adoptive transfer in a CTLA-4 and PD-1–mediated manner.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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