B cell acute lymphoblastic leukemia cells mediate RANK-RANKL–dependent bone destruction-Reference-Cited by-同舟云学术

B cell acute lymphoblastic leukemia cells mediate RANK-RANKL–dependent bone destruction

Published:2020-09-16 Issue:561 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rajakumar Sujeetha A.¹²^ORCID,Papp Eniko²³,Lee Kathy K.⁴⁵^ORCID,Grandal Ildiko³,Merico Daniele⁶^ORCID,Liu Careesa C.⁴⁷,Allo Bedilu⁴^ORCID,Zhang Lucia⁴⁵^ORCID,Grynpas Marc D.⁴⁷,Minden Mark D.²⁸^ORCID,Hitzler Johann K.³⁹^ORCID,Guidos Cynthia J.³¹⁰^ORCID,Danska Jayne S.¹²¹⁰^ORCID

Affiliation:

1. Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

2. Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

3. Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

4. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5T 3H7, Canada.

5. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

6. Center for Applied Genomics, Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

7. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

8. Princess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 2M9, Canada.

9. Department of Pediatrics, Division of Hematology and Oncology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

10. Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Abstract

Primary B-ALL cells cause RANKL-mediated trabecular bone and growth plate destruction in patient-derived xenograft models.

Funder

Leukemia and Lymphoma Society of Canada

Ontario Institute for Cancer Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference80 articles.

1. Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group

2. Acute Lymphoblastic Leukemia in Children

3. Altered mineral metabolism and bone mass in children during treatment for acute lymphoblastic leukemia

4. Longitudinal Evaluation of Bone Mineral Density in Children Receiving Chemotherapy

5. Advanced Vertebral Fracture Among Newly Diagnosed Children With Acute Lymphoblastic Leukemia: Results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) Research Program

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