Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer-Reference-Cited by-同舟云学术

Repurposed floxacins targeting RSK4 prevent chemoresistance and metastasis in lung and bladder cancer

Published:2021-07-14 Issue:602 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chrysostomou Stelios¹^ORCID,Roy Rajat¹^ORCID,Prischi Filippo²³^ORCID,Thamlikitkul Lucksamon¹⁴^ORCID,Chapman Kathryn L.¹⁵,Mufti Uwais¹^ORCID,Peach Robert⁶⁷^ORCID,Ding Laifeng⁸^ORCID,Hancock David⁹^ORCID,Moore Christopher⁹^ORCID,Molina-Arcas Miriam⁹^ORCID,Mauri Francesco¹,Pinato David J.¹^ORCID,Abrahams Joel M.¹,Ottaviani Silvia¹^ORCID,Castellano Leandro¹^ORCID,Giamas Georgios¹⁰^ORCID,Pascoe Jennifer¹¹,Moonamale Devmini¹^ORCID,Pirrie Sarah¹²^ORCID,Gaunt Claire¹²,Billingham Lucinda¹²,Steven Neil M.¹¹^ORCID,Cullen Michael¹¹,Hrouda David¹³^ORCID,Winkler Mathias¹³^ORCID,Post John¹⁴^ORCID,Cohen Philip¹⁴,Salpeter Seth J.¹⁵,Bar Vered¹⁵,Zundelevich Adi¹⁵^ORCID,Golan Shay¹⁶^ORCID,Leibovici Dan¹⁷,Lara Romain¹¹⁸^ORCID,Klug David R.⁶^ORCID,Yaliraki Sophia N.⁶,Barahona Mauricio¹⁹^ORCID,Wang Yulan²⁰^ORCID,Downward Julian⁹^ORCID,Skehel J. Mark²¹^ORCID,Ali Maruf M.U.³^ORCID,Seckl Michael J.¹^ORCID,Pardo Olivier E.¹^ORCID

Affiliation:

1. Division of Cancer, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.

2. School of Biological Sciences, University of Essex, Colchester CO4 3SQ, UK.

3. Department of Life Sciences, Imperial College London, London SW7 2AZ, UK.

4. Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

5. Assay Biology, Domainex Ltd, Cambridge CB10 1XL, UK.

6. Department of Chemistry, Imperial College London, London SW7 2AZ, UK.

7. Department of Neurology, University Hospital Würzburg, 97080 Würzburg, Germany.

8. Key Laboratory of Magnetic Resonance in Biological Systems, National Centre for Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.

9. Oncogene Biology Laboratory, The Francis Crick Institute, London NW1 1AT, UK.

10. Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK.

11. Department of Oncology, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UK.

12. Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham B15 2TT, UK.

13. Department Urology, Charing Cross Hospital, London W6 8RF, UK.

14. MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH. UK.

15. Curesponse, 6 Weizmann Street, 6423906 Tel Aviv, Israel.

16. Department of Urology, Rabin Medical Center, Jabotinsky St. 39, 4941492 Petah Tikva, Israel.

17. Department of Urology, Kaplan Medical Center, 7610001 Rehovot, Israel.

18. AstraZeneca, Discovery Science, R&D, Discovery Biology, Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK.

19. Department of Mathematics, Imperial College London, London SW7 2AZ, UK.

20. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.

21. Biological Mass Spectrometry and Proteomics, MRC LMB, Cambridge CB2 0QH, UK.

Abstract

RSK4 promotes invasiveness and drug resistance in lung and bladder cancer and inhibition of this kinase shows therapeutic potential.

Funder

University of Kentucky

Wellcome

Imperial Oil Limited

Engineering and Physical Sciences Research Council

Cancer Research UK

European Research Council

NIHR Imperial Biomedical Research Centre

Centro Singular de Investigación de Galicia

Cancer Treatment and Research Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference71 articles.

1. The p90 RSK Family Members: Common Functions and Isoform Specificity

2. Paving the way for targeting RSK in cancer

3. Anti-invasive and Antimetastatic Activities of Ribosomal Protein S6 Kinase 4 in Breast Cancer Cells

4. Regulation of Replicative and Stress-Induced Senescence by RSK4, which is Down-regulated in Human Tumors

5. A large-scale RNAi screen in human cells identifies new components of the p53 pathway

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