Long noncoding RNA Chast promotes cardiac remodeling

Author:

Viereck Janika12,Kumarswamy Regalla1,Foinquinos Ariana1,Xiao Ke1,Avramopoulos Petros34,Kunz Meik5,Dittrich Marcus56,Maetzig Tobias7,Zimmer Karina1,Remke Janet1,Just Annette1,Fendrich Jasmin1,Scherf Kristian1,Bolesani Emiliano8,Schambach Axel7,Weidemann Frank910,Zweigerdt Robert8,de Windt Leon J.11,Engelhardt Stefan34,Dandekar Thomas5,Batkai Sandor1,Thum Thomas1212

Affiliation:

1. Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Integriertes Forschungs- und Behandlungszentrum Transplantation (IFB-Tx), Hannover Medical School, D-30625 Hannover, Germany.

2. Excellence Cluster REBIRTH, Hannover Medical School, D-30625 Hannover, Germany.

3. Institute of Pharmacology and Toxicology, Technical University of Munich, D-80802 Munich, Germany.

4. German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, D-80802 Munich, Germany.

5. Department of Bioinformatics, University of Würzburg, D-97074 Würzburg, Germany.

6. Institute of Human Genetics, University of Würzburg, D-97074 Würzburg, Germany.

7. Institute of Experimental Hematology, Hannover Medical School, D-30625 Hannover, Germany.

8. Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, D-30625 Hannover, Germany.

9. Department of Cardiology, Julius-Maximilians University, D-97080 Würzburg, Germany.

10. Comprehensive Heart Failure Center, University of Würzburg, D-97078 Würzburg, Germany.

11. Department of Cardiology, Maastricht University, 6202 AZ Maastricht, Netherlands.

12. National Heart and Lung Institute, Imperial College London, SW3 6NP London, UK.

Abstract

Inhibition of the long noncoding RNA Chast prevents pressure overload–induced cardiac remodeling in mice.

Funder

Integrierte Forschungs- und Behandlungszentrum Transplantation

Deutsche Forschungsgemeinschaft

REBIRTH Excellence Cluster

Fondation Leducq

European Research Council

Hannover Biomedical Research School

Bayerische Forschungsstiftung

German Research Foundation

German Ministry for Education and Science

Innovative Medicines Initiative

European Union

European Federation of Pharmaceutical Industries and Associations

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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