Low α-defensin gene copy number increases the risk for IgA nephropathy and renal dysfunction-Reference-Cited by-同舟云学术

Low α-defensin gene copy number increases the risk for IgA nephropathy and renal dysfunction

Published:2016-06-29 Issue:345 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ai Zhen¹²,Li Ming¹²,Liu Wenting¹²,Foo Jia-Nee³,Mansouri Omniah⁴,Yin Peiran¹²,Zhou Qian¹²,Tang Xueqing¹²,Dong Xiuqing¹²,Feng Shaozhen¹²,Xu Ricong¹²,Zhong Zhong¹²,Chen Jian⁵,Wan Jianxin⁶,Lou Tanqi⁷,Yu Jianwen¹²,Zhou Qin¹²,Fan Jinjin¹²,Mao Haiping¹²,Gale Daniel⁸,Barratt Jonathan⁹,Armour John A. L.⁴,Liu Jianjun³¹⁰¹¹,Yu Xueqing¹²

Affiliation:

1. Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.

2. Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, Guangzhou, Guangdong 510080, China.

3. Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.

4. School of Life Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK.

5. Department of Nephrology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian 350025, China.

6. Department of Nephrology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China.

7. Department of Nephrology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.

8. University College London Centre for Nephrology, Royal Free Hospital, London NW3 2PF, UK.

9. Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, UK.

10. School of Biological Sciences, Anhui Medical University, Hefei, Anhui 230032, China.

11. Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore.

Abstract

Low copy number of the α-defensin DEFA1A3 locus increases the risk for IgA nephropathy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

1. IgA nephropathy;Barratt J.;J. Am. Soc. Nephrol.,2005

2. Natural history of idiopathic IgA nephropathy: Role of clinical and histological prognostic factors;D’Amico G.;Am. J. Kidney Dis.,2000

3. Evidence for genetic factors in the development and progression of IgA nephropathy;Hsu S. I.-H.;Kidney Int.,2000

4. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy;Yu X.-Q.;Nat. Genet.,2012

5. HLA has strongest association with IgA nephropathy in genome-wide analysis;Feehally J.;J. Am. Soc. Nephrol.,2010

Cited by 27 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. An Update on the Genetics of IgA Nephropathy;Journal of Clinical Medicine;2023-12-25

2. Mechanisms and regulation of defensins in host defense;Signal Transduction and Targeted Therapy;2023-08-14

3. Detecting adaptive changes in gene copy number distribution accompanying the human out-of-Africa expansion;2023-08-14

4. Segregation analysis identifies specific alpha‐defensin ( DEFA1A3 ) SNP–CNV haplotypes in predisposition to IgA nephropathy;Annals of Human Genetics;2022-10-10

5. The Gut and Kidney Crosstalk in Immunoglobulin A Nephropathy;Kidney360;2022-09-29