Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet

Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet–fed mice

Published:2016-09-21 Issue:357 Volume:8 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rao Anuradha¹,Kosters Astrid¹,Mells Jamie E.¹,Zhang Wujuan²,Setchell Kenneth D. R.²,Amanso Angelica M.¹,Wynn Grace M.¹,Xu Tianlei³,Keller Brad T.⁴,Yin Hong⁵,Banton Sophia⁶,Jones Dean P.⁶⁷,Wu Hao⁸,Dawson Paul A.¹⁵,Karpen Saul J.¹⁵

Affiliation:

1. Department of Pediatrics, Emory University School of Medicine, 1760 Haygood Drive Northeast, Atlanta, GA 30322, USA.

2. Department of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

3. Department of Mathematics and Computer Science, Emory University, Atlanta, GA 30322, USA.

4. Vasculox Inc., St. Louis, MO 63108, USA.

5. Children’s Healthcare of Atlanta, 2015 Uppergate Drive Northeast, Atlanta, GA 30322, USA.

6. Department of Biochemistry, Emory University, 1510 Clifton Road Northeast, Atlanta, GA 30322, USA.

7. Department of Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA 30322, USA.

8. Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.

Abstract

Inhibition of the ileal bile acid transporter treats multiple features of nonalcoholic steatohepatitis in high-fat diet–fed mice.

Funder

NIH

NIH Fellowship in Research and Science Teaching (FIRST) Institutional Research and Academic Career Development

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference53 articles.

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4. Specific bile acids inhibit hepatic fatty acid uptake in mice

5. Omega-3 polyunsaturated fatty acid and ursodeoxycholic acid have an additive effect in attenuating diet-induced nonalcoholic steatohepatitis in mice

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