The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis-Reference-Cited by-全球学者库

The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis

Published:2017-05-24 Issue:391 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Imamura Keiko¹^ORCID,Izumi Yuishin²^ORCID,Watanabe Akira¹^ORCID,Tsukita Kayoko¹,Woltjen Knut¹³,Yamamoto Takuya¹⁴,Hotta Akitsu¹⁴⁵,Kondo Takayuki¹^ORCID,Kitaoka Shiho¹,Ohta Akira¹^ORCID,Tanaka Akito¹,Watanabe Dai⁶,Morita Mitsuya⁷^ORCID,Takuma Hiroshi⁸,Tamaoka Akira⁸,Kunath Tilo⁹^ORCID,Wray Selina¹⁰,Furuya Hirokazu¹¹^ORCID,Era Takumi¹²,Makioka Kouki¹³,Okamoto Koichi¹⁴,Fujisawa Takao¹⁵,Nishitoh Hideki¹⁶^ORCID,Homma Kengo¹⁵^ORCID,Ichijo Hidenori¹⁵,Julien Jean-Pierre¹⁷,Obata Nanako¹⁸,Hosokawa Masato¹⁸^ORCID,Akiyama Haruhiko¹⁸,Kaneko Satoshi¹⁹,Ayaki Takashi²⁰,Ito Hidefumi²¹^ORCID,Kaji Ryuji⁴^ORCID,Takahashi Ryosuke²⁰^ORCID,Yamanaka Shinya¹²²,Inoue Haruhisa¹^ORCID

Affiliation:

1. Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.

2. Department of Clinical Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.

3. Hakubi Center for Advanced Research, Kyoto University, Kyoto 606-8501, Japan.

4. Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8507, Japan.

5. Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama 332-0012, Japan.

6. Department of Biological Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

7. Division of Neurology, Department of Internal Medicine, Jichi Medical University, Tochigi 329-0498, Japan.

8. Department of Neurology, Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.

9. MRC Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK.

10. Department of Molecular Neuroscience, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.

11. Department of Neurology, Kochi Medical School, Kochi University, Kochi 783-8505, Japan.

12. Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.

13. Department of Neurology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.

14. Geriatrics Research Institute and Hospital, Maebashi 371-0847, Japan.

15. Cell Signaling, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

16. Department of Medical Sciences, University of Miyazaki, Miyazaki 889-1601, Japan.

17. Department of Psychiatry and Neurosciences, Research Centre of Mental Health Institute of Quebec (IUSMQ), Laval University, Québec, Canada.

18. Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan.

19. Department of Neurology, Kansai Medical University, Hirakata 573-1191, Japan.

20. Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

21. Department of Neurology, Wakayama Medical University, Kimiidera, Wakayama 641-8509, Japan.

22. Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.

Abstract

Analysis of ALS patient iPSC-derived motor neurons indicates that Src/c-Abl inhibitors may have potential for treating ALS.

Funder

iPS Cell Research Fund

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Daiichi Sankyo Foundation of Life Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference56 articles.

1. Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

2. Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis

3. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

4. Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

5. Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

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