Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers-Reference-Cited by-同舟云学术

Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

Published:2021-09-22 Issue:612 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Begley C. Glenn¹^ORCID,Ashton Mark²^ORCID,Baell Jonathan³^ORCID,Bettess Michael⁴^ORCID,Brown Michael P.⁵^ORCID,Carter Brett⁶,Charman William N.³,Davis Christopher⁷,Fisher Simon⁸^ORCID,Frazer Ian⁹^ORCID,Gautam Anand¹⁰^ORCID,Jennings Michael P.⁷^ORCID,Kearney Philip¹¹,Keeffe Eloise⁷^ORCID,Kelly Darren¹²^ORCID,Lopez Angel F.¹³^ORCID,McGuckin Michael¹⁴^ORCID,Parker Michael W.¹⁵^ORCID,Rayner Craig¹⁶,Roberts Brett⁸,Rush James S.¹⁷,Sullivan Mark¹⁸^ORCID

Affiliation:

1. 7 Grieve Parade, Altona, Victoria, Australia.

2. UniQuest Pty Ltd., University of Queensland, Brisbane, Queensland, Australia.

3. Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia.

4. Brandon Capital Partners, Melbourne, Victoria, Australia.

5. Cancer Clinical Trials Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

6. Bioseer Pty Ltd., Glen Iris, Victoria, Australia.

7. Institute for Glycomics, Griffith University, Gold Coast campus, Queensland, Australia.

8. Novartis Pharmaceuticals Australia Pty Ltd., Macquarie Park, New South Wales, Australia.

9. University of Queensland Diamantina Institute, Woolloongabba, Queensland, Australia.

10. Pfizer, Melbourne, Victoria, Australia.

11. Merck Sharp & Dohme, Macquarie Park, New South Wales, Australia.

12. Department of Medicine, University of Melbourne, Parkville, Victoria, Australia.

13. Centre for Cancer Biology, Adelaide, South Australia, Australia.

14. University of Melbourne, Parkville, Victoria, Australia.

15. Bio21 Molecular Science and Biotechnology Institute, Parkville, Victoria, Australia.

16. Certara, Parkville, Victoria, Australia.

17. Novartis Pharmaceuticals AG, Basel, Switzerland.

18. Medicines Development for Global Health, Southbank, Victoria, Australia.

Abstract

The assumption that drug repurposing efficiently delivers new drugs ignores the realities of drug development required to achieve regulatory approval.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference83 articles.

1. Drug repositioning: identifying and developing new uses for existing drugs

2. Drug repurposing: progress, challenges and recommendations

3. On-Label or Off-Label? Overcoming Regulatory and Financial Barriers to Bring Repurposed Medicines to Cancer Patients

4. Overcoming the legal and regulatory barriers to drug repurposing

5. The Drug Repurposing Hub: a next-generation drug library and information resource

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