Advances toward transformative therapies for tendon diseases-Reference-Cited by-同舟云学术

Advances toward transformative therapies for tendon diseases

Published:2022-09-07 Issue:661 Volume:14 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Freedman Benjamin R.¹²^ORCID,Mooney David J.¹²^ORCID,Weber Eckhard³^ORCID

Affiliation:

1. John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

3. Novartis Pharma AG, Basel CH 4056, Switzerland.

Abstract

Approved therapies for tendon diseases have not yet changed the clinical practice of symptomatic pain treatment and physiotherapy. This review article summarizes advances in the development of novel drugs, biologic products, and biomaterial therapies for tendon diseases with perspectives for translation of integrated therapies. Shifting from targeting symptom relief toward disease modification and prevention of disease progression may open new avenues for therapies. Deep evidence-based clinical, cellular, and molecular characterization of the underlying pathology of tendon diseases, as well as therapeutic delivery optimization and establishment of multidiscipline interorganizational collaboration platforms, may accelerate the discovery and translation of transformative therapies for tendon diseases.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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