A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma-Reference-Cited by-全球学者库

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

Published:2017-07-19 Issue:399 Volume:9 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

O’Rourke Donald M.¹^ORCID,Nasrallah MacLean P.²^ORCID,Desai Arati³^ORCID,Melenhorst Jan J.⁴^ORCID,Mansfield Keith⁵^ORCID,Morrissette Jennifer J. D.⁶^ORCID,Martinez-Lage Maria²^ORCID,Brem Steven¹^ORCID,Maloney Eileen¹,Shen Angela⁷^ORCID,Isaacs Randi⁵^ORCID,Mohan Suyash⁸,Plesa Gabriela⁴^ORCID,Lacey Simon F.⁴^ORCID,Navenot Jean-Marc⁴^ORCID,Zheng Zhaohui⁴^ORCID,Levine Bruce L.⁴^ORCID,Okada Hideho⁹,June Carl H.⁴^ORCID,Brogdon Jennifer L.⁵,Maus Marcela V.¹⁰^ORCID

Affiliation:

1. Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Division of Neuropathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

6. Division of Precision and Computational Diagnostics, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

7. Novartis Oncology, East Hanover, NJ 07936, USA.

8. Division of Neuroradiology, Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

9. Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA.

10. Cellular Immunotherapy Program, Cancer Center and Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA.

Abstract

A trial of autologous T cells redirected to a specific mutation in glioblastoma patients illustrates mechanisms of resistance.

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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