Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas

Author:

Wang Yuxuan1,Springer Simeon1,Mulvey Carolyn L.2,Silliman Natalie1,Schaefer Joy1,Sausen Mark13,James Nathan1,Rettig Eleni M.2,Guo Theresa2,Pickering Curtis R.4,Bishop Justin A.5,Chung Christine H.6,Califano Joseph A.27,Eisele David W.2,Fakhry Carole27,Gourin Christine G.2,Ha Patrick K.27,Kang Hyunseok6,Kiess Ana8,Koch Wayne M.2,Myers Jeffrey N.4,Quon Harry8,Richmon Jeremy D.2,Sidransky David2,Tufano Ralph P.2,Westra William H.5,Bettegowda Chetan19,Diaz Luis A.1,Papadopoulos Nickolas1,Kinzler Kenneth W.1,Vogelstein Bert1,Agrawal Nishant12

Affiliation:

1. Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute, and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

2. Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

3. Personal Genome Diagnostics, Baltimore, MD 21224, USA.

4. Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA.

5. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

6. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

7. Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, MD 21204, USA.

8. Department of Radiation Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

9. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Abstract

Tumor DNA in saliva and plasma can provide a noninvasive biomarker for head and neck squamous cell carcinoma.

Funder

NIH

NIH/National Institute of Dental and Craniofacial Research (NIDCR)

Conrad R. Hilton Foundation

Virginia and D.K. Ludwig Fund for Cancer Research

Banyan Gate Foundation

Swim Across America

Sol Goldman Sequencing Facility at Johns Hopkins

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

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