Classic reaction kinetics can explain complex patterns of antibiotic action

Author:

Abel zur Wiesch Pia12,Abel Sören34,Gkotzis Spyridon5,Ocampo Paolo67,Engelstädter Jan8,Hinkley Trevor9,Magnus Carsten10,Waldor Matthew K.311,Udekwu Klas5,Cohen Ted1212

Affiliation:

1. Division of Global Health Equity, Brigham and Women’s Hospital and Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA.

2. Department of Epidemiology of Microbial Diseases, Yale School of Public Health, 60 College Street, New Haven, CT 06510, USA.

3. Division of Infectious Diseases, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.

4. Department of Pharmacy, UiT, The Arctic University of Norway, 9037 Tromsø, Norway.

5. Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 17177 Stockholm, Sweden.

6. Institute of Integrative Biology, ETH Zürich, Universitätsstrasse 16, 8092 Zürich, Switzerland.

7. Department of Environmental Microbiology, EAWAG, Überlandstrasse 133, 8600 Dübendorf, Switzerland.

8. School of Biological Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.

9. School of Chemistry, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK.

10. Institute of Medical Virology, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.

11. Howard Hughes Medical Institute, 181 Longwood Avenue, Boston, MA 02115, USA.

12. Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.

Abstract

Chemical reaction kinetics explain three different effects of drug-mediated bacterial killing.

Funder

NIH

Howard Hughes Medical Institute

National Institute of Allergy and Infectious Diseases

Bill & Melinda Gates Foundation

German Academic Exchange Service

Deutsche Forschungsgemeinschaft

Swiss National Science Foundation

Swedish Research Council

Swiss Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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