Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade-Reference-Cited by-同舟云学术

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

Published:2018-01-03 Issue:422 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Samson Adel¹^ORCID,Scott Karen J.¹,Taggart David¹^ORCID,West Emma J.¹,Wilson Erica¹^ORCID,Nuovo Gerard J.²^ORCID,Thomson Simon³^ORCID,Corns Robert³,Mathew Ryan K.¹^ORCID,Fuller Martin J.¹,Kottke Timothy J.⁴,Thompson Jill M.⁴,Ilett Elizabeth J.¹^ORCID,Cockle Julia V.¹^ORCID,van Hille Philip³,Sivakumar Gnanamurthy³,Polson Euan S.¹,Turnbull Samantha J.¹^ORCID,Appleton Elizabeth S.¹,Migneco Gemma¹,Rose Ailsa S.¹^ORCID,Coffey Matthew C.⁵,Beirne Deborah A.³^ORCID,Collinson Fiona J.⁶,Ralph Christy¹^ORCID,Alan Anthoney D.¹^ORCID,Twelves Christopher J.¹,Furness Andrew J.⁷,Quezada Sergio A.⁷^ORCID,Wurdak Heiko¹^ORCID,Errington-Mais Fiona¹^ORCID,Pandha Hardev⁸,Harrington Kevin J.⁹,Selby Peter J.¹^ORCID,Vile Richard G.⁴,Griffin Stephen D.¹^ORCID,Stead Lucy F.¹^ORCID,Short Susan C.¹^ORCID,Melcher Alan A.⁹^ORCID

Affiliation:

1. Leeds Institute of Cancer and Pathology, Faculty of Medicine and Health, University of Leeds, St James’s University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, UK.

2. Ohio State University, Comprehensive Cancer Centre, Columbus, OH 43210, USA.

3. Leeds Teaching Hospitals National Health Service Trust, St James’s University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, UK.

4. Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.

5. Oncolytics Biotech, Calgary, Alberta T2N 1X7, Canada.

6. Leeds Institute of Clinical Trials Research, Faculty of Medicine and Health, University of Leeds, Leeds, West Yorkshire LS2 9JT, UK.

7. University College London, London WC1 6BT, UK.

8. University of Surrey, Guildford GU2 7XH, UK.

9. Institute of Cancer Research, 123 Old Brompton Road, London SW7 3RP, UK.

Abstract

Intravenous infusion of oncolytic reovirus in patients leads to infection of brain tumors, infiltration by cytotoxic T cells, and up-regulation of PD-L1.

Funder

Cancer Research UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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