Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea-Reference-Cited by-同舟云学术

Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea

Published:2018-10-24 Issue:464 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Battaglioli Eric J.¹^ORCID,Hale Vanessa L.²³^ORCID,Chen Jun⁴,Jeraldo Patricio²^ORCID,Ruiz-Mojica Coral¹,Schmidt Bradley A.¹,Rekdal Vayu M.¹^ORCID,Till Lisa M.¹^ORCID,Huq Lutfi²^ORCID,Smits Samuel A.⁵^ORCID,Moor William J.¹,Jones-Hall Yava⁶^ORCID,Smyrk Thomas⁷^ORCID,Khanna Sahil¹,Pardi Darrell S.¹,Grover Madhusudan¹^ORCID,Patel Robin⁸,Chia Nicholas²,Nelson Heidi²,Sonnenburg Justin L.⁵^ORCID,Farrugia Gianrico⁹^ORCID,Kashyap Purna C.¹¹⁰^ORCID

Affiliation:

1. Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

2. Department of Surgery, Mayo Clinic, Rochester, MN, USA.

3. Department of Veterinary Preventive Medicine, Ohio State University, Columbus, OH, USA.

4. Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

5. Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.

6. Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA.

7. Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.

8. Department of Laboratory Medicine and Pathology, Division of Clinical Microbiology, Mayo Clinic, Rochester, MN, USA.

9. Division of Gastroenterology, Mayo Clinic, Jacksonville, FL, USA.

10. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.

Abstract

Increased amino acids in the dysbiotic gut influences susceptibility to Clostridioides difficile infection in mice and humans.

Funder

NIH Office of the Director

Mayo Foundation for Medical Education and Research

Mayo Clinic Center for Individualized Medicine

Minnesota Partnership for Biotechnology

Global Probiotic Council

Kolenkow-Reitz fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference62 articles.

1. High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

2. Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile

3. Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine

4. Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?

5. Effects of Antibiotics on Human Microbiota and Subsequent Disease

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