Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomography

Author:

Ordonez Alvaro A.123ORCID,Wintaco Luz M.45ORCID,Mota Filipa123ORCID,Restrepo Andres F.6,Ruiz-Bedoya Camilo A.123ORCID,Reyes Carlos F.7,Uribe Luis G.8ORCID,Abhishek Sudhanshu123ORCID,D’Alessio Franco R.9ORCID,Holt Daniel P.10ORCID,Dannals Robert F.10ORCID,Rowe Steven P.10ORCID,Castillo Victor R.11,Pomper Martin G.10ORCID,Granados Ulises412ORCID,Jain Sanjay K.12310ORCID

Affiliation:

1. Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

2. Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

3. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

4. Department of Nuclear Medicine, Hospital Internacional de Colombia, Fundación Cardiovascular de Colombia, Piedecuesta 681017, Colombia.

5. Biomedical and Biological Sciences Graduate Program, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá 111711, Colombia.

6. Department of Internal Medicine, Hospital Internacional de Colombia, Fundación Cardiovascular de Colombia, Piedecuesta 681017, Colombia.

7. Department of Critical Care, Hospital Internacional de Colombia, Fundación Cardiovascular de Colombia, Piedecuesta 681017, Colombia.

8. Department of Infectious Diseases, Hospital Internacional de Colombia, Fundación Cardiovascular de Colombia, Piedecuesta 681017, Colombia.

9. Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

10. Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

11. Bioengineering Research Group, Fundación Cardiovascular de Colombia, Piedecuesta 681017, Colombia.

12. Biomedical and Translational Research Group, Fundación Cardiovascular de Colombia, Piedecuesta 681017, Colombia.

Abstract

18 F-FDS PET/CT can detect and localize infections due to Enterobacterales in patients and noninvasively monitor response to antibiotic treatment.

Funder

National Institutes of Health

U.S. Department of Defense

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

Johns Hopkins University

Colciencias

Maryland Innovation Initiative

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

1. M. S. Donnenberg Mandell Douglas and Bennett’s Principles and Practice of Infectious Diseases J. E. B. Gerald L. Mandell R. Dolin Eds. (Elsevier Inc. 2010) chap. 218 pp. 2815–2833.

2. M. N. Guentzel in Medical Microbiology S. Baron Ed. (University of Texas Medical Branch at Galveston 1996) chap. 26.

3. Centers for Disease Control and Prevention Antibiotic Resistance Threats in the United States (Centers for Disease Control and Prevention 2019); https://cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf.

4. A Cohort Study of the Impact of Carbapenem-Resistant Enterobacteriaceae Infections on Mortality of Patients Presenting with Sepsis

5. Organisms causing secondary pneumonias in COVID-19 patients at 5 UK ICUs as detected with the FilmArray test;Dhesi Z.;medRxiv,2020

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