Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis-Reference-Cited by-同舟云学术

Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

Published:2021-09 Issue:609 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Singhal Mahak¹²³^ORCID,Gengenbacher Nicolas¹²³,Abdul Pari Ashik Ahmed¹²³^ORCID,Kamiyama Miki¹²^ORCID,Hai Ling⁴,Kuhn Bianca J.³⁵^ORCID,Kallenberg David M.⁶^ORCID,Kulkarni Shubhada R.¹²^ORCID,Camilli Carlotta⁶^ORCID,Preuß Stephanie F.¹²³^ORCID,Leuchs Barbara⁷^ORCID,Mogler Carolin⁸,Espinet Elisa⁹¹⁰^ORCID,Besemfelder Eva¹,Heide Danijela¹¹^ORCID,Heikenwalder Mathias¹¹^ORCID,Sprick Martin R.⁹¹⁰^ORCID,Trumpp Andreas⁹¹⁰¹²^ORCID,Krijgsveld Jeroen⁵,Schlesner Matthias⁴¹³^ORCID,Hu Junhao¹⁴^ORCID,Moss Stephen E.⁶^ORCID,Greenwood John⁶,Augustin Hellmut G.¹²¹²^ORCID

Affiliation:

1. Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.

2. Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

3. Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany.

4. Junior Group Bioinformatics and Omics Data Analytics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

5. Divison of Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

6. Department of Cell Biology, UCL Institute of Ophthalmology, London EC1V 9EL, United Kingdom.

7. Vector Development and Production Unit, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

8. Institute of Pathology, TUM School of Medicine, 81675 Munich, Germany.

9. Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany.

10. Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.

11. Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

12. German Cancer Consortium, 69120 Heidelberg, Germany.

13. Biomedical Informatics, Data Mining and Data Analytics, Augsburg University, 86159 Augsburg, Germany.

14. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China.

Abstract

A temporal systems biology screen of premetastatic endothelial cells identified LRG1 as a therapeutic target for restricting metastases.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference67 articles.

1. Emerging paradigms in metastasis research

2. The lung microenvironment: an important regulator of tumour growth and metastasis

3. Emerging Biological Principles of Metastasis

4. Targeting metastasis

5. Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

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