Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits

Author:

Liu Yang1ORCID,Dzidotor Godwin23ORCID,Le Thinh T.1ORCID,Vinikoor Tra4ORCID,Morgan Kristin4ORCID,Curry Eli J.5,Das Ritopa4ORCID,McClinton Aneesah2ORCID,Eisenberg Ellen67ORCID,Apuzzo Lorraine N.8ORCID,Tran Khanh T. M.4ORCID,Prasad Pooja8,Flanagan Tyler J.910ORCID,Lee Seok-Woo910ORCID,Kan Ho-Man2,Chorsi Meysam T.1,Lo Kevin W. H.211,Laurencin Cato T.234910ORCID,Nguyen Thanh D.1410ORCID

Affiliation:

1. Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.

2. Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA.

3. Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269, USA.

4. Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.

5. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

6. Division of Oral and Maxillofacial Diagnostic Sciences, School of Dental Medicine, University of Connecticut, Farmington, CT 06030, USA.

7. Division of Anatomic Pathology, Department of Pathology and Laboratory Medicine, School of Medicine, University of Connecticut, Farmington, CT 06030, USA.

8. Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA.

9. Department of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, USA.

10. Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.

11. Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.

Abstract

A biodegradable piezoelectric scaffold excited by exercise promotes chondrogenesis and cartilage regeneration in rabbit osteochondral defects.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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