Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile-Reference-Cited by-同舟云学术

Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile

Published:2012-04-04 Issue:128 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hrkach Jeffrey¹,Von Hoff Daniel²,Ali Mir Mukkaram¹,Andrianova Elizaveta¹,Auer Jason¹,Campbell Tarikh¹,De Witt David¹,Figa Michael¹,Figueiredo Maria¹,Horhota Allen¹,Low Susan¹,McDonnell Kevin¹,Peeke Erick¹,Retnarajan Beadle¹,Sabnis Abhimanyu¹,Schnipper Edward¹,Song Jeffrey J.¹,Song Young Ho¹,Summa Jason¹,Tompsett Douglas¹,Troiano Greg¹,Van Geen Hoven Tina¹,Wright Jim¹,LoRusso Patricia³,Kantoff Philip W.⁴,Bander Neil H.⁵,Sweeney Christopher⁴,Farokhzad Omid C.⁶,Langer Robert⁷,Zale Stephen¹

Affiliation:

1. BIND Biosciences Inc., Cambridge, MA 02139, USA.

2. TGen Clinical Research Services at Scottsdale Healthcare, Phoenix, AZ 85004, USA.

3. Karmanos Cancer Institute, Detroit, MI 48201, USA.

4. Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

5. Weill Cornell Medical College, New York, NY 10065, USA.

6. Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

7. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

A targeted nanoparticle containing docetaxel displays antitumor activity in animals and differentiated pharmacological properties in patients with advanced solid tumors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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