Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells-Reference-Cited by-同舟云学术

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

Published:2012-08 Issue:145 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Egawa Naohiro¹²,Kitaoka Shiho¹²,Tsukita Kayoko¹²,Naitoh Motoko³,Takahashi Kazutoshi¹,Yamamoto Takuya¹⁴,Adachi Fumihiko¹,Kondo Takayuki¹⁵,Okita Keisuke¹,Asaka Isao¹,Aoi Takashi¹,Watanabe Akira¹⁴,Yamada Yasuhiro¹⁴,Morizane Asuka¹⁶,Takahashi Jun¹⁶,Ayaki Takashi⁵,Ito Hidefumi⁵,Yoshikawa Katsuhiro³,Yamawaki Satoko³,Suzuki Shigehiko³,Watanabe Dai⁷,Hioki Hiroyuki⁸,Kaneko Takeshi⁸,Makioka Kouki⁹,Okamoto Koichi⁹,Takuma Hiroshi¹⁰,Tamaoka Akira¹⁰,Hasegawa Kazuko¹¹,Nonaka Takashi¹²,Hasegawa Masato¹²,Kawata Akihiro¹³,Yoshida Minoru¹⁴,Nakahata Tatsutoshi¹,Takahashi Ryosuke⁵,Marchetto Maria C. N.¹⁵,Gage Fred H.¹⁵,Yamanaka Shinya¹⁴¹⁶,Inoue Haruhisa¹²¹⁶

Affiliation:

1. Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.

2. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0076, Japan.

3. Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

4. Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8501, Japan.

5. Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan.

6. Department of Biological Repair, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.

7. Department of Biological Sciences, Graduate School of Medicine and Department of Molecular and Systems Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan.

8. Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.

9. Department of Neurology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.

10. Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305-8576, Japan.

11. Department of Neurology, Sagamihara Hospital, Sagamihara 252-0392, Japan.

12. Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.

13. Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo 183-0042, Japan.

14. Chemical Genetics Laboratory Molecular Ligand Biology Research Team, Chemical Genomics Research Group, RIKEN Advanced Science Institute, Wako, Saitama 351-0198, Japan.

15. The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

16. Yamanaka iPS Cell Special Project, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan.

Abstract

Anacardic acid attenuates mutant TDP-43–associated abnormalities in motor neurons derived from ALS patient–specific induced pluripotent stem cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference30 articles.

1. UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS

2. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

3. Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis