MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways-Reference-Cited by-同舟云学术

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

Published:2012-02-15 Issue:121 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Chau B. Nelson¹,Xin Cuiyan²,Hartner Jochen³⁴,Ren Shuyu²,Castano Ana P.⁴,Linn Geoffrey²,Li Jian¹,Tran Phong T.¹,Kaimal Vivek¹,Huang Xinqiang¹,Chang Aaron N.¹,Li Shenyang⁵,Kalra Aarti⁶,Grafals Monica⁷⁸,Portilla Didier⁵,MacKenna Deidre A.¹,Orkin Stuart H.³⁴,Duffield Jeremy S.²

Affiliation:

1. Regulus Therapeutics, San Diego, CA 92121, USA.

2. Division of Nephrology, Center for Lung Biology, Department of Medicine, and Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.

3. Dana-Farber Cancer Institute, Children’s Hospital, Boston, MA 02215, USA.

4. Harvard Medical School, Boston, MA 02215, USA.

5. Division of Nephrology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

6. Division of Pathology, Lahey Clinic Medical Center, Burlington, MA 01805, USA

7. Division of Transplantation, Lahey Clinic Medical Center, Burlington, MA 01805, USA.

8. Tufts University, Boston, MA 02110, USA.

Abstract

MicroRNA-21 contributes to fibrosis in the kidney by posttranscriptionally regulating lipid metabolism genes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference60 articles.

1. Regulation of Fibrosis by the Immune System

2. Pathogenesis of Liver Fibrosis

3. Serum Amyloid P Inhibits Fibrosis Through FcγR-Dependent Monocyte-Macrophage Regulation in Vivo

4. Targeting Endothelium-Pericyte Cross Talk by Inhibiting VEGF Receptor Signaling Attenuates Kidney Microvascular Rarefaction and Fibrosis

5. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

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