Preexisting BCG-Specific T Cells Improve Intravesical Immunotherapy for Bladder Cancer

Author:

Biot Claire123,Rentsch Cyrill A.124,Gsponer Joel R.124,Birkhäuser Frédéric D.5,Jusforgues-Saklani Hélène12,Lemaître Fabrice67,Auriau Charlotte12,Bachmann Alexander5,Bousso Philippe67,Demangel Caroline8,Peduto Lucie9,Thalmann George N.5,Albert Matthew L.1210

Affiliation:

1. Unité d’Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, F-75724 Paris, France.

2. INSERM U818, F-75654 Paris, France.

3. MINES ParisTech, F-75272 Paris, France.

4. Department of Urology, University Hospital of Basel, CH-4031 Basel, Switzerland.

5. Department of Urology, University of Bern, Inselspital, CH-3010 Bern, Switzerland.

6. Unité des Dynamiques des Réponses Immunes, Department of Immunology, Institut Pasteur, F-75724 Paris, France.

7. INSERM U668, F-75654 Paris, France.

8. Institut Pasteur, Unité d’Immunobiologie de l’Infection, Department of Immunology, F-75015 Paris, France.

9. Unité de Développement des Tissus Lymphoïdes, Department of Immunology, Institut Pasteur, F-75724 Paris, France.

10. Université Paris Descartes, F-75270 Paris, France.

Abstract

Preexisting immunity to BCG improves treatment response to intravesical BCG therapy for bladder cancer in mouse models and humans.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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