PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function-Reference-Cited by-同舟云学术

PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

Published:2012-07-11 Issue:142 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Tsunemi Taiji¹,Ashe Travis D.¹,Morrison Bradley E.¹,Soriano Kathryn R.²,Au Jonathan²,Roque Ruben A. Vázquez³,Lazarowski Eduardo R.⁴,Damian Vincent A.²,Masliah Eliezer³⁵,La Spada Albert R.¹⁵⁶⁷⁸

Affiliation:

1. Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.

2. Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.

3. Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.

4. Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

5. Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.

6. Department of Cellular and Molecular Medicine, University of California, San Diego; La Jolla, CA 92093, USA.

7. Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

8. Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

PGC-1α rescues Huntington’s disease neurodegeneration by reducing reactive oxygen species and inducing a master regulator of autophagy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference62 articles.

1. Clinical Aspects of CAG Repeat Diseases

2. Neuropathological Classification of Huntingtonʼs Disease

3. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

4. Repeat expansion disease: progress and puzzles in disease pathogenesis

5. Protein Fate in Neurodegenerative Proteinopathies: Polyglutamine Diseases Join the (Mis)Fold

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