Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma

Author:

Tanas Munir R.1,Sboner Andrea2,Oliveira Andre M.3,Erickson-Johnson Michele R.3,Hespelt Jessica1,Hanwright Philip J.1,Flanagan John4,Luo Yuling4,Fenwick Kerry5,Natrajan Rachael5,Mitsopoulos Costas5,Zvelebil Marketa5,Hoch Benjamin L.6,Weiss Sharon W.7,Debiec-Rychter Maria8,Sciot Raf9,West Rob B.10,Lazar Alexander J.11,Ashworth Alan5,Reis-Filho Jorge S.5,Lord Christopher J.5,Gerstein Mark B.212,Rubin Mark A.13,Rubin Brian P.1

Affiliation:

1. Department of Molecular Genetics and Anatomic Pathology, Lerner Research Institute, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH 44195, USA.

2. Program in Computational Biology and Bioinformatics and Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.

3. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.

4. Advanced Cell Diagnostics, Hayward, CA 94545, USA.

5. The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK.

6. Department of Anatomic Pathology, University of Washington, Seattle, WA 98195–6100, USA.

7. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA.

8. Department of Human Genetics, Katholieke Universiteit Leuven, Leuven B-3000, Belgium.

9. Department of Pathology, Katholieke Universiteit Leuven, Leuven B-3000, Belgium.

10. Pathology Department, Stanford University Medical Center, Stanford, CA 94305, USA.

11. Department of Pathology and Sarcoma Research Center, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030–4009, USA.

12. Department of Computer Science, Yale University, New Haven, CT 06520, USA.

13. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.

Abstract

A newly identified gene fusion defines the vascular cancer epithelioid hemangioendothelioma and encodes a chimeric transcription factor.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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