Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

Author:

Bettegowda Chetan12,Sausen Mark1,Leary Rebecca J.1,Kinde Isaac1,Wang Yuxuan1,Agrawal Nishant12,Bartlett Bjarne R.13,Wang Hao1,Luber Brandon1,Alani Rhoda M.4,Antonarakis Emmanuel S.1,Azad Nilofer S.1,Bardelli Alberto567,Brem Henry2,Cameron John L.2,Lee Clarence C.8,Fecher Leslie A.910,Gallia Gary L.2,Gibbs Peter1112,Le Dung13,Giuntoli Robert L.2,Goggins Michael2,Hogarty Michael D.13,Holdhoff Matthias1,Hong Seung-Mo214,Jiao Yuchen1,Juhl Hartmut H.15,Kim Jenny J.1,Siravegna Giulia16,Laheru Daniel A.1,Lauricella Calogero16,Lim Michael2,Lipson Evan J.1,Marie Suely Kazue Nagahashi17,Netto George J.2,Oliner Kelly S.18,Olivi Alessandro2,Olsson Louise19,Riggins Gregory J.2,Sartore-Bianchi Andrea16,Schmidt Kerstin1,Shih le-Ming2,Oba-Shinjo Sueli Mieko17,Siena Salvatore16,Theodorescu Dan20,Tie Jeanne11,Harkins Timothy T.8,Veronese Silvio16,Wang Tian-Li2,Weingart Jon D.2,Wolfgang Christopher L.2,Wood Laura D.2,Xing Dongmei2,Hruban Ralph H.2,Wu Jian121,Allen Peter J.22,Schmidt C. Max23,Choti Michael A.2,Velculescu Victor E.1,Kinzler Kenneth W.1,Vogelstein Bert1,Papadopoulos Nickolas1,Diaz Luis A.13

Affiliation:

1. Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

2. Departments of Surgery, Medicine, Pathology, Obstetrics and Gynecology, Otolaryngology, and Neurosurgery at Johns Hopkins, Baltimore, MD 21231, USA.

3. Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21231, USA.

4. Department of Dermatology, Boston University, Boston, MA 02215, USA.

5. Institute for Cancer Research and Treatment at Candiolo, University of Torino, Candiolo, Turin 10060, Italy.

6. Department of Oncology, University of Torino, Candiolo, Turin 10060, Italy.

7. FIRC Institute of Molecular Oncology (IFOM), Milan 20139, Italy.

8. Advanced Applications and Collaborations, Life Technologies, Foster City, CA 94404, USA.

9. Division of Oncology, University of Indiana, Indianapolis, IN 46202, USA.

10. Indiana University Health, Indianapolis, IN 46202, USA.

11. Ludwig Institute for Cancer Research, Melbourne Branch, Royal Melbourne Hospital, Melbourne, Victoria 3084, Australia.

12. Western Hospital, Melbourne, Victoria 3011, Australia.

13. Division of Oncology, The Children’s Hospital of Philadelphia and the Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

14. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.

15. Indivumed GmbH, Hamburg 20251, Germany.

16. Niguarda Cancer Center, Ospedale Niguarda Ca’ Granda, Milan 20162, Italy.

17. Department of Neurology and Pathology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.

18. Amgen Inc., Thousand Oaks, CA 91320, USA.

19. Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm SE-171 76, Sweden.

20. University of Colorado Comprehensive Cancer Center, Aurora, CO 80045, USA.

21. MyGenostics Inc., 801 West Baltimore Street, Baltimore, MD 21205, USA.

22. Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

23. Departments of Surgery, Biochemistry, and Molecular Biology, Indiana University, Indianapolis, IN 46202, USA.

Abstract

Circulating tumor DNA can be used in a variety of clinical and investigational settings across tumor types and stages for screening, diagnosis, and identifying mutations responsible for therapeutic response and drug resistance.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference58 articles.

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