Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance-Reference-Cited by-同舟云学术

Reversal of Persistent Fibrosis in Aging by Targeting Nox4-Nrf2 Redox Imbalance

Published:2014-04-09 Issue:231 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hecker Louise¹²,Logsdon Naomi J.¹,Kurundkar Deepali¹,Kurundkar Ashish¹,Bernard Karen¹,Hock Thomas¹,Meldrum Eric³,Sanders Yan Y.¹,Thannickal Victor J.¹

Affiliation:

1. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

2. Birmingham VA Medical Center, Birmingham, AL 35233, USA.

3. Genkyotex, 1228 Geneva, Switzerland.

Abstract

Fibrosis resolution is impaired by aging and is mediated by altered cellular redox homeostasis because of a Nox4-Nrf2 imbalance that promotes an apoptosis-resistant myofibroblast phenotype.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference45 articles.

1. Wound repair and regeneration

2. Heart regeneration

3. Fibrotic disease and the TH1/TH2 paradigm

4. Idiopathic Pulmonary Fibrosis

5. The Myofibroblast

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