Translating Glutamate: From Pathophysiology to Treatment

Author:

Javitt Daniel C.1,Schoepp Darryle2,Kalivas Peter W.3,Volkow Nora D.4,Zarate Carlos5,Merchant Kalpana6,Bear Mark F.7,Umbricht Daniel8,Hajos Mihaly9,Potter William Z.10,Lee Chi-Ming11

Affiliation:

1. Translational Schizophrenia Research Center, Nathan Kline Institute/Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

2. Neuroscience, Merck and Company Inc., North Wales, PA 19454, USA.

3. Department of Neurosciences, Medical University of South Carolina, Charlestown, SC 29464, USA.

4. National Institute on Drug Abuse, Bethesda, MD 20892, USA.

5. Mood and Anxiety Disorders Research Unit, National Institute of Mental Health, Bethesda, MD 20892, USA.

6. Translational Science, Eli Lilly and Company, Indianapolis, IN 46285, USA.

7. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

8. Neuroscience Pharma Research and Early Development, Central Nervous System, F. Hoffmann–La Roche Ltd., 4070 Basel, Switzerland.

9. Neuroscience Department, CNS Discovery, Pfizer Global Research and Development, Groton, CT 06340, USA.

10. Foundation for the National Institutes of Health Biomarkers Consortium, Bethesda, MD 20814, USA.

11. AstraZeneca Pharmaceuticals, Sodertalje R&D, SE-15185, Sodertalje, Sweden.

Abstract

On 21 to 22 June 2010, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, discussed the role of glutamate in neuropsychiatric disease at the meeting “Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System.”

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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