Identification of a Titin-Derived HLA-A1–Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3–Directed T Cells-Reference-Cited by-同舟云学术

Identification of a Titin-Derived HLA-A1–Presented Peptide as a Cross-Reactive Target for Engineered MAGE A3–Directed T Cells

Published:2013-08-07 Issue:197 Volume:5 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cameron Brian J.¹,Gerry Andrew B.²,Dukes Joseph¹,Harper Jane V.¹,Kannan Vivekanandan¹,Bianchi Frayne C.¹,Grand Francis¹,Brewer Joanna E.²,Gupta Minnal³,Plesa Gabriela³,Bossi Giovanna¹,Vuidepot Annelise¹,Powlesland Alex S.¹,Legg Alison¹,Adams Katherine J.²,Bennett Alan D.²,Pumphrey Nicholas J.²,Williams Daniel D.²,Binder-Scholl Gwendolyn²,Kulikovskaya Irina³,Levine Bruce L.³,Riley James L.⁴,Varela-Rohena Angel⁴,Stadtmauer Edward A.³,Rapoport Aaron P.⁵,Linette Gerald P.⁶,June Carl H.³,Hassan Namir J.¹,Kalos Michael³,Jakobsen Bent K.¹²

Affiliation:

1. Immunocore Ltd., 57c Milton Park, Jubilee Avenue, Abingdon, OX14 4RX, UK.

2. Adaptimmune Ltd., 57c Milton Park, Jubilee Avenue, Abingdon, OX14 4RX, UK.

3. Abramson Cancer Center and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Abramson Cancer Center and Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

5. The Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA.

6. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

T cells engineered to express affinity-enhanced TCRs directed to a MAGE A3 peptide cross-react with a similar, but unrelated, self-peptide.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference46 articles.

1. Adoptive immunotherapy for cancer: harnessing the T cell response

2. Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

3. T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

4. Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

5. Prolonged T cell persistence, homing to marrow and selective targeting of antigen positive tumor in multiple myeloma patients following adoptive transfer of T cells genetically engineered to express an affinity-enhanced T cell receptor against the cancer testis antigens NY-ESO-1 and Lage-1.;Kalos M.;Blood (ASH Annu. Meet. Abstr.),2012

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