Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates-Reference-Cited by-同舟云学术

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

Published:2014-11-05 Issue:261 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yu Y. Joy¹,Atwal Jasvinder K.¹,Zhang Yin²,Tong Raymond K.³,Wildsmith Kristin R.⁴,Tan Christine²,Bien-Ly Nga¹,Hersom Maria¹,Maloney Janice A.¹,Meilandt William J.¹,Bumbaca Daniela⁴,Gadkar Kapil⁴,Hoyte Kwame⁵,Luk Wilman⁵,Lu Yanmei⁵,Ernst James A.³,Scearce-Levie Kimberly¹,Couch Jessica A.⁴,Dennis Mark S.²,Watts Ryan J.¹

Affiliation:

1. Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

2. Antibody Engineering, Genentech Inc., South San Francisco, CA 94080, USA.

3. Protein Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.

4. Development Sciences, Genentech Inc., South San Francisco, CA 94080, USA.

5. Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.

Abstract

Bispecific antibodies engineered to both bind to the primate transferrin receptor and inhibit β-secretase are taken up by the nonhuman primate brain and reduce brain β-amyloid.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference16 articles.

1. Blood–Brain Barrier Transport of Therapeutics via Receptor-Mediation

2. Macromolecular drug transport into the brain using targeted therapy

3. Developing Therapeutic Antibodies for Neurodegenerative Disease

4. Breaching the Blood-Brain Barrier for Drug Delivery

5. Bispecific antibodies for delivery into the brain

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