A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo-Reference-Cited by-同舟云学术

A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo

Published:2011-05-25 Issue:84 Volume:3 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Atwal Jasvinder K.¹,Chen Yongmei²,Chiu Cecilia²,Mortensen Deborah L.³,Meilandt William J.¹,Liu Yichin⁴,Heise Christopher E.⁴,Hoyte Kwame⁵,Luk Wilman⁵,Lu Yanmei⁵,Peng Kun⁶,Wu Ping⁷,Rouge Lionel⁷,Zhang Yingnan⁸,Lazarus Robert A.⁸,Scearce-Levie Kimberly¹,Wang Weiru⁷,Wu Yan²,Tessier-Lavigne Marc¹,Watts Ryan J.¹

Affiliation:

1. Neurodegeneration Labs, Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

2. Department of Antibody Engineering, Genentech, South San Francisco, CA 94080, USA.

3. Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech, South San Francisco, CA 94080, USA.

4. Department of Biochemical Pharmacology, Genentech, South San Francisco, CA 94080, USA.

5. Department of Assay and Automation Technology, Genentech, South San Francisco, CA 94080, USA.

6. Department of BioAnalytical Research and Development, Genentech, South San Francisco, CA 94080, USA.

7. Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA.

8. Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA.

Abstract

A human antibody inhibits BACE1 activity and Aβ peptide production in cultured neurons and in the central nervous system of mouse and monkey.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference33 articles.

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2. What Can Be Inferred from the Interruption of the Semagacestat Trial for Treatment of Alzheimer's Disease?

3. Amyloid Precursor Protein Trafficking, Processing, and Function

4. β-Secretase as a therapeutic target for Alzheimer’s disease

5. J. Varghese BACE: Lead Target for Orchestrated Therapy of Alzheimer’s Disease (Wiley Hoboken 2010) p. 266.

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