Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

Author:

Guevara-Aguirre Jaime1,Balasubramanian Priya23,Guevara-Aguirre Marco1,Wei Min3,Madia Federica3,Cheng Chia-Wei3,Hwang David4,Martin-Montalvo Alejandro56,Saavedra Jannette1,Ingles Sue7,de Cabo Rafael5,Cohen Pinchas4,Longo Valter D.238

Affiliation:

1. Institute of Endocrinology, Metabolism and Reproduction, Quito, Ecuador.

2. Department of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.

3. Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089, USA.

4. Division of Pediatric Endocrinology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

5. Laboratory of Experimental Gerontology, National Institute on Aging, Baltimore, MD 21224, USA.

6. Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide–Consejo Superior de Investigaciones Cientificas and Centre for Biomedical Research on Rare Diseases, ISCIII, E-41013 Sevilla, Spain.

7. Division of Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

8. Norris Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.

Abstract

Ecuadorians who have a genetic mutation in the growth hormone receptor almost never die of cancer or diabetes complications, possibly because of high resistance to oxidative damage and low circulating insulin.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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