Longitudinal Change in CSF Biomarkers in Autosomal-Dominant Alzheimer’s Disease

Author:

Fagan Anne M.12,Xiong Chengjie23,Jasielec Mateusz S.23,Bateman Randall J.12,Goate Alison M.124,Benzinger Tammie L. S.25,Ghetti Bernardino6,Martins Ralph N.7,Masters Colin L.8,Mayeux Richard9,Ringman John M.10,Rossor Martin N.11,Salloway Stephen12,Schofield Peter R.1314,Sperling Reisa A.15,Marcus Daniel25,Cairns Nigel J.1216,Buckles Virginia D.12,Ladenson Jack H.16,Morris John C.1216,Holtzman David M.12,

Affiliation:

1. Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Knight Alzheimer’s Disease Research Center at Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.

4. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.

5. Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

6. Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA.

7. WA Center for Alzheimer’s Research and Care, Edith Cowan University, Perth, Western Australia 6009, Australia.

8. Mental Health Research Institute, University of Melbourne, Melbourne, Victoria 3052, Australia.

9. Department of Neurology, The Taub Institute and the Sergievsky Center, Columbia University, New York, NY 10032, USA.

10. Mary S. Easton Center for Alzheimer’s Disease Research, Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

11. Dementia Research Center, University College London, London WC1N 3BG, UK.

12. Departments of Neurology and Psychiatry, Warren Alpert Medical School of Brown University, Butler Hospital, Providence, RI 02906, USA.

13. Neuroscience Research Australia, Sydney, New South Wales 2031, Australia.

14. School of Medical Sciences, University of New South Wales, Sydney, New South Wales 2031, Australia.

15. Department of Neurology, Brigham and Women’s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

16. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Longitudinal cerebrospinal fluid biomarker analyses reveal decreases in neuronal injury markers in later stages of autosomal-dominant Alzheimer’s disease.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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