Prostaglandin D 2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia-Reference-Cited by-同舟云学术

Prostaglandin D 2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

Published:2012-03-21 Issue:126 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Garza Luis A.¹,Liu Yaping²,Yang Zaixin¹,Alagesan Brinda¹,Lawson John A.³,Norberg Scott M.¹,Loy Dorothy E.⁴,Zhao Tailun¹,Blatt Hanz B.¹,Stanton David C.⁵,Carrasco Lee⁵,Ahluwalia Gurpreet⁶,Fischer Susan M.⁷,FitzGerald Garret A.³,Cotsarelis George¹

Affiliation:

1. Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

2. Screening and Protein Sciences, Merck & Company, North Wales, PA 19454, USA.

3. Department of Pharmacology and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

4. Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

5. Department of Oral and Maxillofacial Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

6. Gillette Corporation, Foxborough, MA 02035, USA.

7. University of Texas M. D. Anderson Cancer Center, Science Park–Research Division, Smithville, TX 78957, USA.

Abstract

Prostaglandin D 2 inhibits hair growth through its receptor, GPR44, and this pathway could serve as a new target for developing treatments for male pattern baldness.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference45 articles.

1. Androgens and hair loss

2. Male-pattern baldness susceptibility locus at 20p11

3. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

4. The Biology of Hair Follicles

5. Association of Benign Prostatic Hyperplasia with Male Pattern Baldness

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