T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway-Reference-Cited by-同舟云学术

T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway

Published:2014-05-07 Issue:235 Volume:6 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bozec Aline¹,Zaiss Mario M.¹²,Kagwiria Rosebeth¹,Voll Reinhard³,Rauh Manfred⁴,Chen Zhu¹,Mueller-Schmucker Sandra¹,Kroczek Richard A.⁵,Heinzerling Lucie⁶,Moser Muriel⁷,Mellor Andrew L.⁸,David Jean-Pierre⁹,Schett Georg¹

Affiliation:

1. Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen 91054, Germany.

2. Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne 1015, Switzerland.

3. Department of Rheumatology and Clinical Immunology, University of Freiburg, Freiburg 79085, Germany.

4. Department of Paediatrics, University of Erlangen-Nuremberg, Erlangen 91054, Germany.

5. Molecular Immunology, Robert Koch Institute, Berlin 13353, Germany.

6. Department of Dermatology, University of Erlangen-Nuremberg, Erlangen 91054, Germany.

7. Department of Molecular Biology, Université Libre de Bruxelles, Gosselies 6041, Belgium.

8. Bradley-Turner and Georgia Research Alliance Eminent Scholar in Molecular Immunogenetics, Georgia Regents University, Augusta, GA 30912, USA.

9. Institute of Osteology and Biomechanics, University Medical Center, Hamburg-Eppendorf, Hamburg 20246, Germany.

Abstract

Costimulatory molecules CD80/CD86 suppress osteoclast differentiation by inducing indoleamine 2,3-dioxygenase.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference40 articles.

1. Molecular regulation of osteoclast activity

2. Genetic regulation of osteoclast development and function

3. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

4. Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

5. TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

Cited by 138 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Immune checkpoint inhibitors in bone metastasis: Clinical challenges, toxicities, and mechanisms;Journal of Bone Oncology;2023-12

2. The Notch1 signaling pathway directly modulates the human RANKL-induced osteoclastogenesis;Scientific Reports;2023-12-01

3. Changes in bone turnover markers and bone modulators during abatacept treatment;Scientific Reports;2023-10-11

4. Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends;Signal Transduction and Targeted Therapy;2023-08-28

5. New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis;Bone Research;2023-05-22