Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus-Reference-Cited by-同舟云学术

Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus

Published:2012-06-13 Issue:138 Volume:4 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ensign Laura M.¹²,Tang Benjamin C.¹²,Wang Ying-Ying¹³,Tse Terence A.¹²,Hoen Timothy¹⁴,Cone Richard¹⁴,Hanes Justin¹²³⁵⁶

Affiliation:

1. Center for Nanomedicine, Johns Hopkins University School of Medicine, 400 North Broadway, Baltimore, MD 21231, USA.

2. Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.

3. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.

4. Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA.

5. Departments of Neurosurgery and Oncology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA.

6. Center for Cancer Nanotechnology Excellence, Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

Abstract

Mucus-penetrating particles improve drug delivery to the mucosal surface of the mouse vagina and deliver acyclovir for enhanced protection against vaginal herpes infection in mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

1. Nanoparticle-based vaginal drug delivery systems for HIV prevention

2. A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections

3. Why consider vaginal drug administration?

4. Microbicide Efficacy and Toxicity Tests in a Mouse Model for Vaginal Transmission of Chlamydia trachomatis

5. Vaginal distribution of two volumes of the novel microbicide gel cellulose sulfate (2.5 and 3.5 mL)

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